The Collagen-Binding Protein Cnm Is Required for Streptococcus mutans Adherence to and Intracellular Invasion of Human Coronary Artery Endothelial Cells

Blocking the collagen-binding protein Cnm in Streptococcus mutans may prevent patients from developing infective endocarditis or coronary atherosclerosis.  Streptococcus mutans, a predominantly hard tissue (tooth) colonizer, is considered the primary etiologic agent of dental caries, an infectious disease that affects 60 to 90% of the population worldwide.  Streptococcus mutans was the most frequently detected bacteria ... Read more

The Effect of Dental Care on Cardiovascular Disease Outcomes: an Application of Instrumental Variables in the Presence of Heterogeneity and Self-Selection

This is an extensive epidemiologic study based on the Health and Retirement Study (HRS), a biennial longitudinal survey of individuals over 50 years old (and spouses).  The data from 1996, 1998, 2000, 2002 and 2004 was included. Although there are limitations to the study, most notably lack of information on detailed dental treatment procedures, they found ... Read more

Reactive Oxygen Species and Antioxidant Defense Mechanisms in the Oral Cavity: A Literature Review

Through dental procedures and environment, periodontal tissues are exposed to many types of reactive oxygen species (ROS). Recently, various forms of antioxidants have been introduced as an approach to fight dental diseases and improve general gingival health. This article focuses on the classification of antioxidants and the link between oxidative stress and periodontal disease. The ... Read more

Use of Antioxidants in Oral Healthcare

There is increasing attention to the potential benefit from the use of antioxidants in the field of dental medicine. In general, antioxidants may be available through oral ingestion, diet or vitamin supplements, and in nutraceuticals. In addition, treatment of oral and dental health problems may include drug-free, natural antioxidant remedies that are available in topical ... Read more

The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: Peiodontitis and Atheroscloerotic Cardiovascular Disease

Aim of this document is to provide health professionals, especially cardiologists and periodontists, a better understanding of the link between atherosclerotic cardiovascular disease and periodontitis. In recent years, the immune system, once believed to be only a vital defense against infection and a promoter of healing--except in the instances of a few uncommon connective tissue ... Read more

Rheumatoid arthritis and periodontal disease

The prevalence of peiodontal disease has increased two-fold amoung patients with rheumatoid arthritis (RA) compared to the general population. This increased prevalence reflects shared pathogenic mechanisms, including an increased prevalences of the shared epitope HLA-DRB1-04; exacerbated T-cell responsiveness withhigh tissue levels of IL-17; exaggerated B-cell responses, with plasma cells being the predominant cell type found ... Read more