the latest research available online
Most cast dental restorations are made from alloys or commercially pure titanium (cpTi). Many orthodontic appliances are also fabricated from metallic materials. It has been documented in vitroand in vivo that metallic dental devices release metal ions, mainly due to corrosion. Those metallic components may be locally and systemically distributed and could play a role ... Read more
Adverse tissue reactions of the gingiva and the periodontium - such as enhanced gingivitis and periodontitis - close to dental cast alloys may be caused by the effects of released metal elements. Tissue reactions depend upon the amounts of elements available which are a function of corrosion rates.
Periodontitis is an oral disease that is not limited to local tissue destruction. Escalating evidence over 20 years of research suggests there are various inflammatory pathways that link periodontitis to systemic damage. These etiological mechanisms are all metastatic in nature, and include the following:• Metastatic spread of gram negative bacteria that gain access to the ... Read more
The increase in ROS and RNS may have been the event that led to the consumption and reduction of salivary antioxidant systems, thus explaining the oxidative damage to the DNA and proteins, and possibly the promotion of OSCC. The oxidized proteins and DNA found in the saliva of the cancer patients seems to be the ... Read more
Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head ... Read more
Following surgical or periodontal procedures, the oral surgeon and dental hygiene team — not to mention the patient — turn their focus to wound healing. During the healing process, we address infection by using antibacterial agents. But healing also depends on controlling inflammation, and in the fight against inflammation, antibacterials are only one weapon in ... Read more
Patients with periodontal disease display increased bacterial antigen PMN number and activity; this proliferation results in high degree of free radical release culminating in heightened oxidative damage to gingival tissues, periodontal ligament and alveolar bone. Damage mediated by free radicals can be mitigated by “ANTIOXIDANT DEFENSE SYSTEM “. Physiological alteration and pathological states produced by ... Read more
This study investigated the role of saliva in the pathogenesis of Oropharyngeal (OP) cancer, which is usually squamous cell carcinoma, the most common head and neck malignancy and accounts for 2 to 4% of all new cancers, and is primarily induced by exposure to tobacco. A synergistic effect of cigarette smoke (CS) and saliva on ... Read more
This in vitro study evaluates the antioxidant substances present in the human diet with an antimutagenic productive capacity against genotoxic damage induced by exposure to X-rays in an attempt to reduce biological damage to as low a level as reasonably possible.
Oral cancer’s much higher prevalence among older people may be due to an age-related reduction in protective salivary antioxidant mechanisms and/or an age-related increase in the magnitude of oral carcinogen attack, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), causing DNA aberrations. This study found a significantly reduced total value of salivary antioxidant ... Read more