The effect of an antioxidant gel compared to chlorhexidine during the soft tissue healing process: An animal study
This is the first evidence in an animal model that the AO gel (PerioSciences) healed gingival wounds faster than Chlorhexidine.
Article Type: Peer Review Study Links
Periodontal systemic associations: review of the evidence
This review found that while the definitions used to identify periodontitis were fairly heterogeneous, very few studies met a stringent threshold for periodontitis. Published evidence supports modest associations between some, although not all, of the diseases and conditions reviewed: respiratory disease, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome and cancer.
Infection and inflammatory mechanisms
This introductory article examines the potential mechanisms that may play a role in the associations between periodontitis and the systemic conditions being considered in the EFP/AAP Workshop in Segovia, Spain. Three basic mechanisms have been postulated to play a role in these interactions: metastatic infections, inflammation and inflammatory injury, and adaptive immunity. The potential role ... Read more
Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study
Diabetes mellitus (DM) has been linked with oxidative stress and decreased antioxidant defense. A connection has been established between diabetes and periodontal disease. This study concludes total antioxidant capacity is inversely proportional to the severity of inflammation and can be used as a useful marker of periodontitis in healthy and diabetic patients.
Assessment of Salivary and Serum Antioxidant Vitamins and Lipid Peroxidation in Ptaients with Recurrent Aphthous Ulceration
Recurrent aphothous ulcerations (RAU), or Canker sores, is a common oral mucosal disorder. This study's data indicate that RAU patients have higher oxidative stress and signficantly lower amounts of antioxidant vitamins A, E and C than in healthy control subjects.
Antioxidant combinations protect oral fibroblasts against metal-induced toxicity
In dentistry, metals are often used. Previous studies revealed that zinc (Zn) and copper (Cu) released from gold alloys, and nickel (Ni) released from nickel-chromium alloys, have a highly cytotoxic effect on fibroblast cell cultures. This study data indicate that pure antioxidants counteracted the detrimental effects of Cu, Ni and Zn on oral fibroblasts in ... Read more
Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms
Further investigation is necessary to fully translate basic research into clinical studies and practice regarding potential biological pathways underlying the possible association between periodontal disease and adverse pregnancy outcomes. Understanding the systemic virulence potential of the individual's oral microbiome and immune response may be a distinctly different issue from categorizing the nature of the challenge ... Read more
Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
Research into possible associations between periodontitis and various systemic diseases and conditions do not imply causality, and establishment of causality will require new studies. Precise and community-agreed case definitions of periodontal disease states must be implemented systematically to enable consistent and clearer interpretations. Studies should focus on robust disease outcomes and avoid surrogate endpoints.
Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
There is consistent and strong epidemiologic evidence that periodontitis imparts increased risk for future cardiovascular disease; and while in vitro, animal and clinical studies support the interaction and biological mechanism, intervention trials to date are not adequate to draw further conclusions. Well-designed intervention trials on the impact of periodontal treatment on prevention of atherosclerotic cardiovascular ... Read more
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology
Despite the lack of evidence that periodontal bacteria obtained from human atheromas can cause atherosclerosis in animal models of infection, attainment of proofs 1 to 6 (out of 7) provides support that periodontal pathogens can contribute to atherosclerosis. Gathered data were categorized into 7 "proofs" of evidence that periodontal bacteria: 1) disseminate from the oral ... Read more