Article Type: Peer Review Study Links

Despite the proven cytotoxicity, poly(methylmethacrylate) (PMMA) resin is one of the most frequently and extensively used materials in medical and dental fields. The study examined the potential detoxification of the resin material and restoration of the resin-induced suppression of cellular function using an antioxidant amino acid derivative, N-acetyl cysteine (NAC). The data demonstrated that the ... Read more

The aim of this study was to investigate the effect of mineral trioxide aggregate (MTA) on cell viability and mineralization ability of rat dental pulp cells. The pulp capping materials, such as MTA, Dycal (Dentsply Caulk, Milford, DE), and Superbond C&B (SB; Sun Medical, Shiga, Japan) were placed on transwell inserts and cultured with rat ... Read more

The authors found that dental bonding substances tested alone or in combination with composites are far more cytotoxic than composite materials alone. These data are in line with several cytotoxicity reports but contradict in vivo studies showing the beneficial effects of bonding materials. The aims of the present study were to develop a preparation method for ... Read more

Purpose: To compare the cytotoxicity of five one-step dentin-bonding agents on human dental pulp and odontoblast-like cells (MDPC-23). Conclusion: These results indicate that one-step dentin-bonding agents differ markedly in their cytotoxicity. Differential cytotoxic effects of one-step dentin-bonding agents should be considered during clinical application of operative restoration. Methodology: Photopolymerized and unpolymerized samples of these dentin-bonding ... Read more

Residual monomers in resin-based biomaterials cause cytotoxicity. We previously showed that methyl methacrylate (MMA) induced mRNA expression of the glutathione S-transferase alpha 1 gene (Gsta1) located downstream of the cis-acting anti-oxidant responsive element (ARE). Herein, we tested the hypothesis that MMA activated the Gsta1 promoter through the ARE. HepG2 cells were transfected with a luciferase ... Read more

There is concern that dental-resin materials directly loaded on a prepared tooth adversely affect dental pulp tissue by releasing the resin chemicals through dentinal tubes. This study determined whether self-curing polymethyl methacrylate (PMMA)-based dental resin extract adversely affected the viability and function of odontoblast-like cells and whether the cytotoxicity of this resin, if any, could ... Read more

The cytotoxicity of four methacrylate resin-based sealers was investigated by the 3-(4,5-dimethyl-thiazoyl)-2,5-diphenyl-tetrazolium bromide assay, which measures cell viability by assessing its succinate dehydrogenase activity. The sealers were polymerized in the self-cured mode to simulate the setting condition upon their extrusion into periradicular tissues. After setting, they were placed in direct contact with rat osteosarcoma (ROS 17/2.8) ... Read more

This study was designed to evaluate the cytotoxicity of several resin-based cements (Panavia F, Super-Bond C&B, Chemiace II) after polymerization on cultured human dental pulp cells. After polymerization, three resin-based cements (Panavia F, Super-Bond C&B, Chemiace II) induced slight cytotoxicity. The sensitivity of cytotoxicity to human pulp cells depended on the resin-based cements and the ... Read more

This in vitro study aims to evaluate three different base materials (acetal, heat-polymerized, and auto-polymerized resins) on L-929 mouse fibroblast cells over 1 h-, 1-, 3-, 5-, 7-day periods. The hypothesis was that acetal resin would show higher cytotoxic effect than heat-polymerized and auto-polymerized acrylic resins, as it seems possible that residual formaldehyde might be ... Read more

The objective of this study was to test the hypothesis that various light curing units (LCUs) have an influence on the cytotoxic action of adhesive systems. Significance: In practice, one should use combinations of dental adhesive and LCU in which the material has the least toxic influences.