Peer Review Study Links Archives - Page 13 of 16

Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride.

Dysfunction of salivary glands is often associated with aging and cancer therapy. Green tea polyphenols were previously found to protect normal epithelial cells from reactive oxygen species, and to induce apoptosis in tumor cells. The current study investigated whether -(-) epigallocatechin-3-gallate (EGCG), the major green tea polyphenol, protects normal salivary gland cells from the effects of ... Read more

Role of p21WAF1 in green tea polyphenol-induced growth arrest and apoptosis of oral carcinoma cells.

The cyclin-dependent kinase inhibitor p21WAF1 participates in cell growth, differentiation, and apoptosis. p21WAF1 can be induced by green tea polyphenol EGCG in several cancer cell types...

Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in pregnant women with chronic periodontitis

There is evidence of reduced antioxidant (AO) defense in periodontitis and pregnancy and adverse interactions between periodontitis and pregnancy.

Polyphenolic beverages reduce initial bacterial adherence to enamel in situ

Polyphenols are antibacterial and anti-oxidative natural agents. The present in situ study aimed to investigate the effect of different polyphenolic beverages on initial bacterial adherence to enamel in the oral cavity. Rinses with all beverages reduced the amount of detectable bacteria. Lowest number of adherent bacteria was found following rinses with red wine, Cistus tea ... Read more

Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy.

Periodontal disease emerged as a clear risk factor for stillbirth but no interventions have reduced stillbirth rates.

The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways

BisGMA released from composite resin may potentially affect the vitality of dental pulp and induce pulpal inflammation via stimulation of ROS production, MEK/ERK1/2 activation and subsequent COX-2 gene expression and PGE(2) production. Cytotoxicity of BisGMA to dental pulp cells is related to ROS production.

Total antioxidant capacity of saliva and its relation with early childhood caries and rampant caries.

Dental caries is an infectious and communicable disease and multiple factors influence the initiation and progression of the disease. Recently it has been claimed that oxidative stress may play an important role in the onset and the development of several inflammatory oral pathologies and dental caries may also be included. Saliva could constitute a first ... Read more

Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients.

An increase in the oxidative stress in oral squamous cell carcinoma patients is associated with a deficient antioxidant defense mechanism. This oxidant-antioxidant imbalance may be considered as one of the factors responsible for pathogenesis of cancer. Future studies regarding assessment of oxidant-antioxidant status in OSCC patients in view of selecting appropriate mode of therapy and ... Read more

Reaction kinetics of sodium ascorbate and dental bleaching gel.

The aim of this study was to establish the reaction kinetics of 35% hydrogen peroxide and sodium ascorbate and to determine the mass of antioxidant required to neutralize the bleaching gel. The results indicated a direct correlation between the mass of hydrogen peroxide and that of the antioxidant agent. In addition, 5 minutes of contact ... Read more

Melatonin in diseases of the oral cavity.

Melatonin may play a role in protecting the oral cavity from tissue damage caused by oxidative stress. The experimental evidence suggests that melatonin may have utility in the treatment of several common diseases of the oral cavity. However, more specific studies are necessary to extend the therapeutic possibilities to other oral diseases.

Featured Research

The effect of an antioxidant gel compared to chlorhexidine during the soft tissue healing process: An animal study

This is the first evidence in an animal model that the AO gel (PerioSciences) healed gingival wounds faster than Chlorhexidine.

Bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblasts

Antioxidants (AO) are the first line of defence against free radical damage and are critical for maintaining optimum health and well being. The need for AOs becomes even more critical...

Antioxidants Counteract Nicotine and Promote Migration via RacGTP in Oral Fibroblast Cells

Smoking is associated with increased risk for oral health and dental problems. The aim of this study is to address the hypothesis that nicotine impairs wound healing by increasing reactive...

Poster: Bioactive Polyphenol Antioxidants Protect Oral Fibroblasts from ROS Inducing Agents

Oral tissues acquire oxidative damage from exposure to free radicals generated by lifestyle choices, the environment and some dental procedures. In this study, hydrogen peroxide (H2O2), ethanol (EtOH) and nicotine...

What is Dry Mouth?

Dry mouth, or xerostomia, is the sensation that there is not enough saliva (spit) to keep your mouth moist. While everyone feels parched occasionally—usually due to dehydration or stress—chronic dry...

Antioxidant combinations protect oral fibroblasts against metal-induced toxicity

In dentistry, metals are often used. Previous studies revealed that zinc (Zn) and copper (Cu) released from gold alloys, and nickel (Ni) released from nickel-chromium alloys, have a highly cytotoxic...

Salivary antioxidants and oral health in children with autism

101 subjects with autism between ages 6 and 12 year were part of this study, along with 50 normal healthy siblings of the same age group as the control group, to evaluate...

Management of Bisphosphonate-Related Osteonecrosis with a Topical Antioxidant Gel

Case studies of 3 patients with Bisphosphonate-related osteonecrosis of the jaw (BRONJ) which concludes that antioxidants topically applied to areas of BRONJ represent a component of treatment that when combined...

Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agents

Oxidative damage to soft oral tissues may result from exposure to the chemicals or biochemicals found in teeth-whitening products, dental restorations, tobacco, and alcohol. In this study, the antioxidant combinations...

Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile

Periodontal infection itself does not cause atherosclerosis, but it accelerates it by inducing systemic inflammation and deterioriating lipd metabolism, particularly when underlying hyperlidemia or susceptibility to hyperlipidemia exists, and it...

Impact of Periodontitis on the Diabetes-Related Inflammatory Status

This review attempts to explain the immunobiological connection between periodontal diseases and type 2 diabetes mellitus, exploring the mechanisms through which periodontal infection can contribute to the low-grade general inflammation...

Prevalence of Oral HPV Infection in the United States, 2009-2010

Human papillomavirus (HPV) infection is the principal cause of a distinct form of oropharyngeal squamous cell carcinoma that is increasing in incidence among men in the United States. Human papillomavirus–positive...

The Impact of Smoking Status on Antioxidant Enzyme Activity and Malondialdehyde Levels in Chronic Periodontitis

This study investigates the impact of smoking status on the systemic and local superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities and malondialdehyde (MDA) levels in subjects with chronic...

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

Oral Health Behaviors, Periodontal Disease, and Pathogens in Preeclampsia: A Case-Control Study in Korea

Preeclampsia is a pregnancy-specific disease characterized by hypertension and proteinuria. This disease occurs in 3% of pregnant women in developing countries and remains one of the major causes of maternal...