the latest research available online
Dry mouth, or xerostomia, is the sensation that there is not enough saliva (spit) to keep your mouth moist. While everyone feels parched occasionally—usually due to dehydration or stress—chronic dry mouth occurs when your salivary glands don't produce enough saliva to function normally which can affect your teeth, gums and digestion.
Diabetes mellitus (DM) has been linked with oxidative stress and decreased antioxidant defense. A connection has been established between diabetes and periodontal disease. This study concludes total antioxidant capacity is inversely proportional to the severity of inflammation and can be used as a useful marker of periodontitis in healthy and diabetic patients.
Recurrent aphothous ulcerations (RAU), or Canker sores, is a common oral mucosal disorder. This study's data indicate that RAU patients have higher oxidative stress and signficantly lower amounts of antioxidant vitamins A, E and C than in healthy control subjects.
In dentistry, metals are often used. Previous studies revealed that zinc (Zn) and copper (Cu) released from gold alloys, and nickel (Ni) released from nickel-chromium alloys, have a highly cytotoxic effect on fibroblast cell cultures. This study data indicate that pure antioxidants counteracted the detrimental effects of Cu, Ni and Zn on oral fibroblasts in ... Read more
Case studies of 3 patients with Bisphosphonate-related osteonecrosis of the jaw (BRONJ) which concludes that antioxidants topically applied to areas of BRONJ represent a component of treatment that when combined with antimicrobial agents may promote healing. The treatment is non-invasive and well tolerated by patients. No deleterious side effects of the antioxidant gel were reported. ... Read more
Oxidative damage to soft oral tissues may result from exposure to the chemicals or biochemicals found in teeth-whitening products, dental restorations, tobacco, and alcohol. In this study, the antioxidant combinations of resveratrol, ferulic acid and tetrahydrocurcuminoid (RFT), phloretin, ferulic acid and resveratrol (PFR), phloretin, ferulic acid and tetrahydrocurcuminoid (PFT) protected the oral fibroblasts from the ... Read more
This study on mice marks the first documented case in microbiology of a keystone pathogen (a low-abundance species that has disproportionate influence on its environment), catalyzing the onset of an oral disease. Porphyromonas gingivalis attacks front-line immune cells in the subgingival crevice, and reprograms them to create living conditions conducive to P. gingivalis growth. As ... Read more
Previous research has found reduced salivary antioxidant activity in patients suffering from periodontal disease. An improved understanding of the role antioxidants play in periodontitis, and the influence of nutrition on antioxidant status, may lead to a possible nutritional strategy for the treatment of periodontal disease.
The study findings suggest that topical application of cetylated monounsaturated fatty acid complex, 1-tetradecanol complex (1-TDC), is a potential therapeutic approach in controlling the progression of chronic periodontal disease.
The increase in ROS and RNS may have been the event that led to the consumption and reduction of salivary antioxidant systems, thus explaining the oxidative damage to the DNA and proteins, and possibly the promotion of OSCC. The oxidized proteins and DNA found in the saliva of the cancer patients seems to be the ... Read more