the latest research available online
Polyphenols are antibacterial and anti-oxidative natural agents. The present in situ study aimed to investigate the effect of different polyphenolic beverages on initial bacterial adherence to enamel in the oral cavity. Rinses with all beverages reduced the amount of detectable bacteria. Lowest number of adherent bacteria was found following rinses with red wine, Cistus tea ... Read more
Periodontal disease emerged as a clear risk factor for stillbirth but no interventions have reduced stillbirth rates.
BisGMA released from composite resin may potentially affect the vitality of dental pulp and induce pulpal inflammation via stimulation of ROS production, MEK/ERK1/2 activation and subsequent COX-2 gene expression and PGE(2) production. Cytotoxicity of BisGMA to dental pulp cells is related to ROS production.
Dental caries is an infectious and communicable disease and multiple factors influence the initiation and progression of the disease. Recently it has been claimed that oxidative stress may play an important role in the onset and the development of several inflammatory oral pathologies and dental caries may also be included. Saliva could constitute a first ... Read more
An increase in the oxidative stress in oral squamous cell carcinoma patients is associated with a deficient antioxidant defense mechanism. This oxidant-antioxidant imbalance may be considered as one of the factors responsible for pathogenesis of cancer. Future studies regarding assessment of oxidant-antioxidant status in OSCC patients in view of selecting appropriate mode of therapy and ... Read more
The aim of this study was to establish the reaction kinetics of 35% hydrogen peroxide and sodium ascorbate and to determine the mass of antioxidant required to neutralize the bleaching gel. The results indicated a direct correlation between the mass of hydrogen peroxide and that of the antioxidant agent. In addition, 5 minutes of contact ... Read more
Melatonin may play a role in protecting the oral cavity from tissue damage caused by oxidative stress. The experimental evidence suggests that melatonin may have utility in the treatment of several common diseases of the oral cavity. However, more specific studies are necessary to extend the therapeutic possibilities to other oral diseases.
The aetiopathogenesis of periodontal diseases is initiated by microbial biofilm which could lead to a hyperinflammatory status in aggressive forms of the disease; and cause an imbalance in the redox status, resulting in oxidative stress-induced damage. There is increasing documentation of the link between periodontal and other inflammatory diseases driven by a pro-oxidant profile. This ... Read more
Reactive oxygen species (ROS) are believed to be involved in radiation-induced xerostomia, and the application of antioxidants may be a promising method for treating patients suffering from salivary gland dysfunction. We believe that our results may advance the potential application of antioxidants for the prevention of ROS-induced xerostomia.
Heat stress induced the production of reactive oxygen species and the increased expression of the interleukin (IL)-8 and IL-8 receptor genes. Exposure of cells to heat stress resulted in the nuclear translocation of Nrf2 and increased expression of Nrf2 target genes including heme oxygenase-1. Pretreatment with an exogenous antioxidant inhibited the heat-induced expression of IL-8 ... Read more