Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agents

Oxidative damage to soft oral tissues may result from exposure to the chemicals or biochemicals found in teeth-whitening products, dental restorations, tobacco, and alcohol. In this study, the antioxidant combinations of resveratrol, ferulic acid and tetrahydrocurcuminoid (RFT), phloretin, ferulic acid and resveratrol (PFR), phloretin, ferulic acid and tetrahydrocurcuminoid (PFT) protected the oral fibroblasts from the detrimental effects of hydrogen peroxide (H2O2), ethanol (EtOH) and nicotine (Nic) by decreasing total reactive oxygen species (ROS) and increasing cell viability and DNA synthesis.

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