The role of reactive oxygen and antioxidant species in periodontal tissue destruction

This review focuses predominantly on the role of reactive oxygen species (ROS) and antioxidant defense systems in the pathology of periodontitis, with a view to identifying specific therapeutic targets for future host-modulating therapies.

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Featured Research

The effect of an antioxidant gel compared to chlorhexidine during the soft tissue healing process: An animal study

This is the first evidence in an animal model that the AO gel (PerioSciences) healed gingival wounds faster than Chlorhexidine.

Bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblasts

Antioxidants (AO) are the first line of defence against free radical damage and are critical for maintaining optimum health and well being. The need for AOs becomes even more critical...

Antioxidants Counteract Nicotine and Promote Migration via RacGTP in Oral Fibroblast Cells

Smoking is associated with increased risk for oral health and dental problems. The aim of this study is to address the hypothesis that nicotine impairs wound healing by increasing reactive...

Poster: Bioactive Polyphenol Antioxidants Protect Oral Fibroblasts from ROS Inducing Agents

Oral tissues acquire oxidative damage from exposure to free radicals generated by lifestyle choices, the environment and some dental procedures. In this study, hydrogen peroxide (H2O2), ethanol (EtOH) and nicotine...

What is Dry Mouth?

Dry mouth, or xerostomia, is the sensation that there is not enough saliva (spit) to keep your mouth moist. While everyone feels parched occasionally—usually due to dehydration or stress—chronic dry...

Antioxidant combinations protect oral fibroblasts against metal-induced toxicity

In dentistry, metals are often used. Previous studies revealed that zinc (Zn) and copper (Cu) released from gold alloys, and nickel (Ni) released from nickel-chromium alloys, have a highly cytotoxic...

Salivary antioxidants and oral health in children with autism

101 subjects with autism between ages 6 and 12 year were part of this study, along with 50 normal healthy siblings of the same age group as the control group, to evaluate...

Management of Bisphosphonate-Related Osteonecrosis with a Topical Antioxidant Gel

Case studies of 3 patients with Bisphosphonate-related osteonecrosis of the jaw (BRONJ) which concludes that antioxidants topically applied to areas of BRONJ represent a component of treatment that when combined...

Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agents

Oxidative damage to soft oral tissues may result from exposure to the chemicals or biochemicals found in teeth-whitening products, dental restorations, tobacco, and alcohol. In this study, the antioxidant combinations...

Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile

Periodontal infection itself does not cause atherosclerosis, but it accelerates it by inducing systemic inflammation and deterioriating lipd metabolism, particularly when underlying hyperlidemia or susceptibility to hyperlipidemia exists, and it...

Impact of Periodontitis on the Diabetes-Related Inflammatory Status

This review attempts to explain the immunobiological connection between periodontal diseases and type 2 diabetes mellitus, exploring the mechanisms through which periodontal infection can contribute to the low-grade general inflammation...

Prevalence of Oral HPV Infection in the United States, 2009-2010

Human papillomavirus (HPV) infection is the principal cause of a distinct form of oropharyngeal squamous cell carcinoma that is increasing in incidence among men in the United States. Human papillomavirus–positive...

The Impact of Smoking Status on Antioxidant Enzyme Activity and Malondialdehyde Levels in Chronic Periodontitis

This study investigates the impact of smoking status on the systemic and local superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities and malondialdehyde (MDA) levels in subjects with chronic...

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients. Read More

Oral Health Behaviors, Periodontal Disease, and Pathogens in Preeclampsia: A Case-Control Study in Korea

Preeclampsia is a pregnancy-specific disease characterized by hypertension and proteinuria. This disease occurs in 3% of pregnant women in developing countries and remains one of the major causes of maternal...