The authors found that dental bonding substances tested alone or in combination with composites are far more cytotoxic than composite materials alone. These data are in line with several cytotoxicity reports but contradict in vivo studies showing the beneficial effects of bonding materials. The aims of the present study were to develop a preparation method for composite specimens modelling conditions in the oral cavity and to analyse the influence of bonding substances on the cytotoxicity of six different composite materials.
This study demonstrates that cell culture toxicity data are highly model dependent and that internationally standardized test protocols for toxicity screening of dental materials in line with the existing standards are clearly needed to obtain comparable results.
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